Abstract
An improved synthetic procedure of racemic bicyclo[3.3.1]nonane-2,6-dione
has been developed. Employing Baker’s yeast for sweet dough
made it possible to kinetically resolve the racemic compound and
to isolate enantiomerically pure (+)-bicyclo[3.3.1]nonane-2,6-dione
on a large scale. Furthermore, the developed procedure made it possible
to produce (-)-bicyclo[3.3.1]nonane-2,6-dione
with an enantiomeric excess of 75%.
Key words
kinetic resolution - bicyclic compounds - synthesis - ketones - chirality
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