Abstract
Neoechinulin A isolated from Eurotium rubrum showed cytoprotection
activity against peroxynitrite generated from SIN-1 [3-(4-morpholinyl)sydnonimine
hydrochloride] in PC12 cells. As we are interested in this
biological activity, we synthesized neoechinulin A and its derivatives.
In this article, we fully report the isolation of natural neoechinulin
A and B, a total synthesis of (-)-neoechinulin A, and determination
of the absolute configuration of natural neoechinulin A. In addition,
we describe herein syntheses of neoechinulin A derivatives, including
a biotinylated neoechinulin A derivative, which will be useful for
identification of the binding proteins of neoechinulin A.
Key words
alkaloids - natural products - indoles - amino
acids - antibiotics
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