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Dtsch Med Wochenschr 2008; 133(39): 1958-1962
DOI: 10.1055/s-0028-1085603
Arzneimittel & Pharmakotherapie | Review article
Neurologie
© Georg Thieme Verlag KG Stuttgart · New York

Olanzapin

OlanzapineK. Wittköpper1 , A. El-Armouche1 , T. Eschenhagen1
  • 1Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg
Further Information

Publication History

eingereicht: 1.2.2008

akzeptiert: 14.5.2008

Publication Date:
16 September 2008 (online)

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Einleitung

Olanzapin (Zyprexa®) ist ein zur chemischen Klasse der Thienobenzodiazepin-Derivate gehörender Serotonin-Dopamin-Rezeptorantagonist. Es wurde 1996 in der EU nach Clozapin und Risperidon als drittes atypisches Neuroleptikum zur Behandlung schizophrener Störungen eingeführt. Es ist mit Clozapin, dem Prototyp dieser Arzneimittelgruppe, chemisch eng verwandt.

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Katrin Wittköpper

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg

Martinistraße 52

20246 Hamburg

Phone: 040 42803/2180

Fax: 040 42803/4876