Abstract
The addition of acyl anion equivalents to aliphatic aldehydes
(crossed-acyloin reaction) has been developed. Cesium fluoride with
isopropanol as solvent promotes the addition of O -silyl thiazolium
carbinols to various aliphatic aldehydes in moderate to good yields.
These reactions represent a general procedure for the selective
coupling of aliphatic aldehydes by an acyl anion reaction which
have been problematic until now.
Key words
acyloin reaction - carbinols - cesium fluoride - acyl anions - thiazolium
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