A Versatile Synthesis of Heterocyclic
Analogues of Neoflavonoids from ­Enamino Ketones

Viktoria S. Moskvina; Volodymir P. Khilya; Olexander V. Turov; Ulrich M. Groth

doi:10.1055/s-0028-1088030

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Synthesis 2009(8): 1279-1286
DOI: 10.1055/s-0028-1088030

PAPER

A Versatile Synthesis of Heterocyclic Analogues of Neoflavonoids from Enamino Ketones

Viktoria S. Moskvina*^a, Volodymir P. Khilya^a, Olexander V. Turov^a, Ulrich M. Groth^b
^a Kyiv National Taras Shevchenko University, Volodymyrska str. 60, Kyiv 01033, Ukraine
Fax: +380(44)2351273; e-Mail: V.Moskvina@gmail.com;
^b Fachbereich Chemie, Universität Konstanz, Fach M-720, Universitätsstr. 10, 78457 Konstanz, Germany

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Publication History

Received 6 August 2008
Publication Date:
25 March 2009 (online)

Abstract
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Abstract

An efficient and versatile one-step method for the synthesis of heterocyclic analogues of neoflavonoids, such as pyrazolyl-, isoxazolyl-, pyrimidinyl-substituted 4-phenyl-2H-chromen-2-ones and fused 4-phenyl-2H,6H-pyrano[3,2-g]chromene-2,6-diones and 4-phenyl-2H,10H-pyrano[2,3-f]chromene-2,10-diones, using the corresponding enamino ketones is described.

Key words

heterocycles - 4-phenyl-2H-chromen-2-one - 2H-1-benzopyran-2-one - neoflavone - enamino ketone - regioselectivity

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