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Synthesis 2009(8): 1255-1260
DOI: 10.1055/s-0028-1088037
DOI: 10.1055/s-0028-1088037
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Facile and General Synthesis of 2β-Aminosteroids
Further Information
Publication History
Received
20 November 2008
Publication Date:
25 March 2009 (online)


Abstract
A facile and general synthesis of 2β-aminosteroids in high yields from 2,3α-epoxy-5α-androstan-17-one by regioselective aminolysis is developed using a zinc chloride/water catalytic system. The reaction is successful with both aliphatic and aromatic amines as well as with azoles.
Key words
amino alcohols - steroids - amines - epoxides - regioselectivity