A facile and general synthesis of 2β-aminosteroids in high
yields from 2,3α-epoxy-5α-androstan-17-one by
regioselective aminolysis is developed using a zinc chloride/water
catalytic system. The reaction is successful with both aliphatic
and aromatic amines as well as with azoles.
amino alcohols - steroids - amines - epoxides - regioselectivity