New Stereoselective Synthesis of Paeonilactone B

Abstract

A new stereoselective synthesis of paeonilactone B has been achieved in ten steps and in 11.5% overall yield starting from the enantiomerically enriched terpenol 2. Key synthetic steps are based on a regioselective metalation and on a regio- and diastereoselective epoxidation.

Key words

natural product - terpene - metalation - homoallylic epoxidation - lactone

References

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