An Inexpensive Procedure for Reductive
Aminations Using Dimethylamineborane on Millimolar and
Molar Scale

Regina Ortmann; Martin Schlitzer

doi:10.1055/s-0028-1088046

PSP

An Inexpensive Procedure for Reductive Aminations Using Dimethylamineborane on Millimolar and Molar Scale

Regina Ortmann, Martin Schlitzer*
Institute of Pharmaceutical Chemistry, Philipps Universität Marburg, Marbacher Weg 6, 35032 Marburg, Germany
Fax: +49(6421)2825953; e-Mail: Schlitzer@staff.uni-marburg.de;

Abstract

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Abstract

We have developed an inexpensive and easy procedure for reductive aminations using dimethylamineborane instead of cyanoborohydride. Dimethylamineborane is easily prepared from readily available inexpensive starting materials and can be used without isolation even on molar scale.

Key words

amines - aminations - hydrides - imines - medicinal chemistry

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References

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Manuscript in preparation.