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Synthesis 2009(10): 1757-1759  
DOI: 10.1055/s-0028-1088046
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© Georg Thieme Verlag Stuttgart ˙ New York

An Inexpensive Procedure for Reductive Aminations Using Dimethylamineborane on Millimolar and Molar Scale

Regina Ortmann, Martin Schlitzer*
Institute of Pharmaceutical Chemistry, Philipps Universität Marburg, Marbacher Weg 6, 35032 Marburg, Germany
Fax: +49(6421)2825953; e-Mail: Schlitzer@staff.uni-marburg.de;
Further Information

Publication History

Received 23 January 2009
Publication Date:
14 April 2009 (online)

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Abstract

We have developed an inexpensive and easy procedure for reductive aminations using dimethylamineborane instead of cyanoborohydride­. Dimethylamineborane is easily prepared from readily available inexpensive starting materials and can be used without isolation even on molar scale.

Key words

amines - aminations - hydrides - imines - medicinal chemistry

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Manuscript in preparation.