Magnesium-Cadmium Chloride,
a Bimetallic Catalyst System for the Allylation of Aldehydes
with Allyl Bromide: An Efficient Protocol for the Synthesis
of Homoallylic Alcohols

A. Venkat Narsaiah; A. Ramesh Reddy; Y. Gopala Rao; E. Vijay Kumar; R. S. Prakasham; Basi V. Subba Reddy; Jhillu S. Yadav

doi:10.1055/s-0028-1093170

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Synthesis 2008(21): 3461-3464
DOI: 10.1055/s-0028-1093170

PAPER

Magnesium-Cadmium Chloride, a Bimetallic Catalyst System for the Allylation of Aldehydes with Allyl Bromide: An Efficient Protocol for the Synthesis of Homoallylic Alcohols

A. Venkat Narsaiah*^a, A. Ramesh Reddy^a, Y. Gopala Rao^a, E. Vijay Kumar^b, R. S. Prakasham^b, Basi V. Subba Reddy^a, Jhillu S. Yadav^a
^a Organic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Fax: +91(40)27160387; e-Mail: vnakkirala2001@yahoo.com;
^b Bioengineering and Environmental Centre, Indian Institute of Chemical Technology, Hyderabad 500 007, India

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Publication History

Received 23 June 2008
Publication Date:
16 October 2008 (online)

Abstract
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Abstract

A simple and efficient procedure for the allylation of aldehydes has been developed using the magnesium-cadmium chloride reagent system. This bimetallic catalytic system works well in a tetrahydrofuran-water solvent medium. A variety of aldehydes undergo smooth nucleophilic addition with allyl bromide to afford the corresponding homoallylic alcohols in excellent yields. All the reactions were performed at room temperature.

Key words

aldehydes - homoallylic alcohols - bimetallic catalyst - allyl bromide

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