Dtsch Med Wochenschr 2008; 133(45): 2345-2348
DOI: 10.1055/s-0028-1100926
Arzneimittel und Pharmakotherapie | Review article
Pharmakologie, Onkologie
© Georg Thieme Verlag KG Stuttgart · New York

Posaconazol: Ein weiteres Triazol-Antimykotikum der neuen Generation?

Posaconazole: Another triazole antifungal of the new generation?C. Müller1 , V. Kohl1 , F. Farowski2 , O. A. Cornely2 , 3
  • 1Institut für Pharmakologie, Uniklinik Köln
  • 2Klinik I für Innere Medizin, Uniklinik Köln
  • 3Zentrum für Klinische Studien (BMBF 01KN0706), Klinikum der Universität zu Köln
Further Information

Publication History

eingereicht: 18.4.2008

akzeptiert: 11.9.2008

Publication Date:
28 October 2008 (online)

Literatur

  • 1 Aktories F. et al .Allgemeine und spezielle Pharmakologie und Toxikologie. München; Urban & Fischer 2005
  • 2 Cornely O A. et al . Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.  N Engl J Med. 2007;  356 348-359
  • 3 Fachinformation zu Noxafil® SEB. 2007, Oktober
  • 4 Hof H. A new, broad-spectrum azole antifungal: posaconazole--mechanisms of action and resistance, spectrum of activity.  Mycoses. 2006;  49 Suppl 1 2-6
  • 5 Keating G M. Posaconazole.  Drugs. 2005;  65 1553-1567; discussion 1568 – 1559
  • 6 Muller C. et al . HPLC analysis of the antifungal agent posaconazole in patients with haematological diseases.  Mycoses. 2006;  49 Suppl 1 17-22
  • 7 Pitisuttithum P. et al . Activity of posaconazole in the treatment of central nervous system fungal infections.  J Antimicrob Chemother. 2005;  56 745-755
  • 8 Raad II. et al . Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections.  Clin Infect Dis. 2006;  42 1726-1734
  • 9 Raad II. et al . Novel antifungal agents as salvage therapy for invasive aspergillosis in patients with hematologic malignancies: posaconazole compared with high-dose lipid formulations of amphotericin B alone or in combination with caspofungin.  Leukemia. 2008;  22 496-503
  • 10 Smith J. et al . Therapeutic drug monitoring of antifungals: pharmacokinetic and pharmacodynamic considerations.  Ther Drug Monit. 2008;  30 167-172
  • 11 Ullmann A J. et al . Pharmacokinetics, safety, and efficacy of posaconazole in patients with persistent febrile neutropenia or refractory invasive fungal infection.  Antimicrob Agents Chemother. 2006;  50 658-666
  • 12 Ullmann A J. et al . Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease.  N Engl J Med. 2007;  356 335-347
  • 13 Walsh T J. et al . Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial.  Clin Infect Dis. 2007;  44 2-12
  • 14 Wexler D. et al . Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study.  Eur J Pharm Sci. 2004;  21 645-653

Dr. med. Carsten Müller

Institut für Pharmakologie, Universität zu Köln

Gleueler Str. 24

50931 Köln

Phone: 0221/478-5066

Fax: 0221/478-7184

Email: c.mueller@uni-koeln.de