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Klin Monbl Augenheilkd 2009; 226(4): 370-371
DOI: 10.1055/s-0028-1109282
DOI: 10.1055/s-0028-1109282
Der interessante Fall
© Georg Thieme Verlag KG Stuttgart · New York
Optic Disc Dysplasia in Cerebral Gray Matter Heterotopias: a Valuable Clinical Clue
Papillendysplasie des Sehnervs bei Heterotopie der zerebralen grauen Substanz: ein wertvoller klinischer HinweisFurther Information
Publication History
Publication Date:
21 April 2009 (online)
![](https://www.thieme-connect.de/media/klimo/200904/lookinside/thumbnails/10.1055-s-0028-1109282-1.jpg)
Background
Nodular gray matter heterotopias are clusters of ectopic neurons that failed to migrate from the embryonic ventricular zone to the developing cerebral cortex [1] [4] [6]. Rarely, optic disc anomalies have been described in association with this cerebral pathology [2] [3].
References
- 1 Bardovich A J, Kuzniecky R I. Gray matter heterotopia. Neurology. 2000; 55 1603-1608
- 2 Brodsky M C, Glasier C M. Optic nerve hypoplasia: clinical significance of associated central nervous system abnormalities on magnetic resonance imaging. Arch Ophthalmol. 1993; 111 66-74
- 3 Brodsky M C. Congenital optic disk anomalies. Surv Ophthalmol. 1994; 39 89-112
- 4 Dubeau F, Tampieri D, Lee N. et al . Periventricular and subcortical nodular heterotopia: a study of 33 patients. Brain. 1995; 118 1273-1287
- 5 Dutton G N. Congenital disorders of the optic nerve: excavations and hypoplasia. Eye. 2004; 18 1038-1048
- 6 Leventer R J, Guerrini R, Dobyns W B. Malformations of cortical development and epilepsy. Dialogues Clin Neurosci. 2008; 10 47-62
Professeur Avinoam B. Safran
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