In-Vivo Quantification of Wall Motion in Cerebral Aneurysms from 2D Cine Phase Contrast Magnetic Resonance Images

Zusammenfassung

Ziel: Die quantitative Charakterisierung der Wandbewegung zerebraler Aneurysmen ist von großem Interesse, um ein besseres Verständnis der Ruptierung zu entwickeln, um genauere Computersimulationen durchführen zu können und um theoretische Modelle dieser vaskulären Erkrankungen zu validieren. Material und Methoden: Mittels Phasen-Kontrast-Magnetresonanztomografie (2D pcMRI) und quantitativer Magnetresonanztomografie (QMRA) wurde die lokale Wandbewegung in sieben zerebralen Aneurysmen in 2 (in einem Falle 3) Querschnittschichten, welche senkrecht zueinander orientiert wurden, gemessen. Ergebnisse: Werte für die maximale Wanddehnung reichten von 0,16 – 1,6 mm (Mittelwert 0,67 mm) und Werte für die maximale Wandkontraktion von –1,91 bis –0,34 mm (Mittelwert –0,94 mm). Im Durchschnitt betrug die Wandauslenkung 0,04 – 0,31 mm (Mittelwert 0,15 mm). Statistisch signifikante Korrelationen zwischen den Bluteinflusskurven und der Wandauslenkung wurde in 7 der 15 Querschnittsschichten gefunden und in 6 der 15 Querschnittsschichten bestand eine statistisch signifikante Korrelation zwischen der Bewegung des Massenzentrums der Wand und der Einflusskurven (p-value < 0,05). Schlussfolgerung: Mittels Phasen-Kontrast-Magnetresonanztomografie (2D pcMRI) und quantitativer Magnetresonanztomografie (QMRA) kann die Wandbewegung zerebraler Aneurysmen quantifiziert werden; jedoch ist die Anwendung dieser Methode begrenzt durch ihre limitierte räumliche Auflösung.

Abstract

Purpose: The quantification of wall motion in cerebral aneurysms is of interest for the assessment of aneurysmal rupture risk, for providing boundary conditions for computational simulations and as a validation tool for theoretical models. Materials and Methods: 2D cine phase contrast magnetic resonance imaging (2D pcMRI) in combination with quantitative magnetic resonance angiography (QMRA) was evaluated for measuring wall motion in 7 intracranial aneurysms. In each aneurysm, 2 (in one case 3) cross sections, oriented approximately perpendicular to each other, were measured. Results: The maximum aneurysmal wall distention ranged from 0.16 mm to 1.6 mm (mean 0.67 mm), the maximum aneurysmal wall contraction was –1.91 mm to –0.34 mm (mean 0.94 mm), and the average wall displacement ranged from 0.04 mm to 0.31 mm (mean 0.15 mm). Statistically significant correlations between average wall displacement and the shape of inflow curves (p-value < 0.05) were found in 7 of 15 cross sections; statistically significant correlations between the displacement of the luminal boundary center point and the shape of inflow curves (p-value < 0.05) were found in 6 of 15 cross sections. Conclusion: 2D pcMRI in combination with QMRA is capable of visualizing and quantifying wall motion in cerebral aneurysms. However, application of this technique is currently restricted by its limited spatial resolution.

brain - aneurysm - MR angiography

References

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