Antifungal Triterpene Glycosides from the Sea Cucumber Holothuria (Microthele) axiloga

Abstract

Three new holostan-type triterpene glycosides, arguside F (1), impatienside B (2), and pervicoside D (3), together with a known saponin, holothurin B (4) were isolated from the sea cucumber Holothuria (Microthele) axiloga H. L. Clark. On the basis of spectroscopic data and chemical reactions, the structures of the new compounds were elucidated. Compound 2 showed significant antifungal activities against six strains (1 ≤ MIC₈₀ ≤ 4 µg/mL). The stereochemistry of holothurin B (4) isolated from the title sea cucumber was also solved through X‐ray diffraction analysis.

Key words

sea cucumber - Holothuria (Microthele) axiloga - Holothuriidae - triterpene glycosides - antifungal - X‐ray diffraction analysis

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