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DOI: 10.1055/s-0029-1185438
© Georg Thieme Verlag KG Stuttgart · New York
New Cytotoxic Lupane Triterpenes from Perrottetia arisanensis
Publication History
received May 14, 2008
revised January 7, 2009
accepted January 27, 2009
Publication Date:
18 March 2009 (online)
Abstract
Eight new lupane triterpenes, including 7β-cis-coumaroylbetulinic acid (1), 7β-trans-coumaroylbetulinic acid (2), 7β-cis-coumaroyl-3-epi-betulinic acid (3), 7β-trans-coumaroyl-3-epi-betulinic acid (4), 7β-cis-coumaroylbetulonic acid (5), 7β-trans-coumaroylbetulonic acid (6), 7β-hydroxybetulinaldehyde (7) and 28-norlup-20(29)-ene-3α,17β-diol (8), together with fifteen known compounds were isolated from the bioactive methanol extract of the stems of Perrottetia arisanensis. The structures of the new compounds were elucidated by spectroscopic and HR‐ESI‐MS analysis. All new compounds were evaluated for their cytotoxicity against six human cancer cell lines. Among them, lupane triterpene coumaroyl esters 1–6 showed moderate cytotoxicity with IC50 values ranging from 3.75 to 21.29 µM. This is the first report for lupane triterpenes with a phenylpropane moiety substituted at C-7.
Key words
Perrottetia arisanensis - Celastraceae - 7‐phenylpropanyllupanes - cytotoxicity
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Prof. Dr. Yang-Chang Wu
Graduate Institute of Natural Products
Kaohsiung Medical University
Kaohsiung 807
Taiwan
R. O. C.
Phone: + 88 6 73 12 11 01 ext.21 97
Fax: + 88 6 73 11 47 73
Email: yachwu@kmu.edu.tw
Prof. Dr. Fang-Rong Chang
Graduate Institute of Natural Products
Kaohsiung Medical University
Kaohsiung 807
Taiwan
R. O. C.
Phone: + 88 6 73 12 11 01 ext.21 62
Email: aaronfrc@kmu.edu.tw
- www.thieme-connect.de/ejournals/toc/plantamedica