Sesquiterpene Lactone 12,8-Eudesmanolides from the Fungus Xylaria ianthinovelutina

Abstract

The investigation of Xylaria ianthinovelutina (Mont.) led to the isolation of four new 12,8-eudesmanolides (1–4). Their structures were determined by spectroscopy and the relative stereochemistry was assigned based on NOESY and CD spectral data. Compounds 1–4 exhibited biological activity against Plasmodium falciparum K-1 strain, NCI-H187, KB, MCF-7 with IC₅₀ values varying in the range 0.78–19.15 µg/mL.

Xylariaceae - Xylaria - Xylaria ianthinovelutina - sesquiterpene lactones - 12,8‐eudesmanolides

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