Planta Med 2010; 76(5): 464-466
DOI: 10.1055/s-0029-1186227
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Antibacterial Compounds from Mushrooms II: Lanostane Triterpenoids and an Ergostane Steroid with Activity Against Bacillus cereus Isolated from Fomitopsis pinicola

Xue-Ting Liu1 , Abby L. Winkler2 , William R. Schwan2 , Thomas J. Volk3 , Marc Rott2 , Aaron Monte1
  • 1Department of Chemistry, University of Wisconsin – La Crosse, La Crosse, Wisconsin, USA
  • 2Department of Microbiology, University of Wisconsin – La Crosse, La Crosse, Wisconsin, USA
  • 3Department of Biology, University of Wisconsin – La Crosse, La Crosse, Wisconsin, USA
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Publikationsverlauf

received August 25, 2009 revised September 14, 2009

accepted September 23, 2009

Publikationsdatum:
21. Oktober 2009 (online)

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Abstract

Anti−Bacillus cereus bioassay-guided fractionation of a crude extract of the American mushroom, Fomitopsis pinicola, was performed using thin-layer chromatography, Sephadex LH-20 column chromatography, and preparative-scale HPLC. Five lanostane triterpenoids (15) and one ergostane steroid (6) were isolated and identified. Compound 1 is a new lanostane triterpenoid, and its structure was determined using 1D and 2D NMR experiments, HR‐MS, and physical data. Each of the purified compounds (16) was tested for antibacterial activity against B. cereus using standard MIC assays. Compounds 16 had MIC values of 32, 16, 32, 32, 128, and 64 µg/mL, respectively.

References

Prof. Aaron Monte

Department of Chemistry
University of Wisconsin – La Crosse

1725 State Street

La Crosse, WI 54601

USA

Telefon: + 1 60 87 85 82 60

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eMail: monte.aaro@uwlax.edu