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DOI: 10.1055/s-0029-1202770
© Georg Thieme Verlag KG Stuttgart · New York
Ophthalmic Manifestation of Candida: Case Report and Review of the Literature
Publication History
received August 11, 2008
accepted after revision November 27, 2008
Publication Date:
15 April 2009 (online)
Abstract
Candidemia in the pediatric burn population poses a management dilemma due to the paucity of good clinical data to guide treatment decisions. Whilst candidemia is less common than bacteremia in pediatric burns patients, it is associated with significant morbidity and mortality. We report a case of candidemia in an infant with 40% burns with ophthalmic complications secondary to nappy rash. We review the investigation and management of ocular candidemia.
Key words
candida ophthalmic manifestation - pediatric burn - nappy rash - antifungal therapy - candidemia
References
- 1 Babay H, Twum-Danso K, Kambal A. et al . Bloodstream infections in pediatric patients. Saudi Med J. 2005; 26 ((10)) 1555-1561
- 2 Benjamin Jr DR, Garges H, Steinbach W. Candida bloodstream infection in neonates. Semin Perinatol. 2003; 27 ((5)) 375-383
- 3 Bliss JM, Wellington M, Gigliotti F. Antifungal pharmacotherapy for neonatal candidiasis. Semin Perinatol. 2003; 27 ((5)) 365-374
- 4 Blyth CC, Palasanthiran P, O'Brien TA. Antifungal therapy in children with invasive fungal infections: A systemic review. Pediatr. 2007; 119 ((4)) 772-784
- 5 Caksen H, Kurtoglu S, Oztürk A. et al . Use of fluconazole in newborn infants with systemic candidiasis. Indian J Pediatr. 2001; 68 ((8)) 797-799
- 6 Chadová L, Bouska I, Toupalík P. Lethal burn trauma in children. Acta Chir Plast. 2000; 42 ((2)) 60-63
- 7 Dotis J, Evdoridou J, Kremenopoulos G. et al . Survey of neonatal candidiasis in Greece. Eur J Clin Microbiol Infect Dis. 2005; 24 ((11)) 749-752
- 8 Hovi L, Saxen H, Saarinen-Pihkala UM. et al . Prevention and monitoring of invasive fungal infections in pediatric patients with cancer and hematologic disorders. Pediatr Blood Cancer. 2007; 48 ((1)) 28-34
- 9 Knoppert DC, Salama HE, Lee DS. Eradication of severe neonatal systemic candidiasis with amphotericin B lipid complex. Ann Pharmacother. 2001; 35 ((9)) 1032-1036
- 10 Kontoyiannis DP. A clinical perspective for the management of invasive fungal infections: focus on IDSA guidelines. Pharmacother. 2001; 21 ((8 Pt 2)) 175S-187S
- 11 McDonnell M, Isaacs D. Neonatal systemic candidiasis. J Paediatr Child Health. 1995; 31 ((6)) 490-492
- 12 Garcia-San Miguel L, Cobo J, Martos I. et al . Risk factors of candidemia in pediatric patients with congenital heart disease. Infect Control Hosp Epidemiol. 2006; 27 ((6)) 576-580
- 13 Moreira M. Controversies about the management of invasive fungal infections in very low birth weight infants. J Pediatr (Rio J). 2005; 81 ((Suppl 1)) S52-S58
- 14 Neely AN, Odds EC, Basatia BK. et al . Characterization of Candida isolates from pediatric burn patients. J Clin Microbiol. 1988; 26 ((9)) 1645-1649
- 15 Odio CM, Araya R, Pinto LE. et al . Caspofungin therapy of neonates with invasive candidiasis. Pediatr Infect Dis. 2004; 23 ((12)) 1093-1097
- 16 Pappas PG, Kauffmann CA, Andes D. et al . Clinical Practice Guidelines for the Management of Candidiasis 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2009; 48 ((5)) 503-535
- 17 Rao S, Ali U. Systemic fungal infections in neonates. J Postgrad Med. 2005; 51 ((Suppl 1)) S27-S29
- 18 Saiman L, Ludington E, Dawson JD. et al . Risk factors for Candida species colonization of neonatal intensive care unit patients. Pediatr Infect Dis. 2001; 20 ((12)) 1119-1124
- 19 Sharma PN, Bang RL, Al-Fadhli AN. et al . Paediatric burns in Kuwait: Incidence, causes and mortality. Burns. 2006; 32 104-111
- 20 Sheridan RL, Remensnyder JP, Schnitzer JJ. et al . Current expectations for survival in pediatric burns. Arch Pediatr Adolesc Med. 2000; 154 ((3)) 245-249
- 21 Sheridan RL. Sepsis in pediatric burn patients. Pediatr Crit Care Med. 2005; 6 ((Suppl 3)) S112-S119
- 22 Sheridan RL, Weber JM, Budkevich LG. et al . Candidemia in the pediatric patient with burns. J Burn Care Rehab. 1995; 16 ((4)) 440-443
Correspondence
Dr. J. Ha
Telstra Burns Unit
Royal Perth Hospital
Wellington Street Campus
6000 Perth
Australia
Phone: +61/4/2130 06 58
Fax: +61/8/9224 17 19
Email: jenha81@yahoo.com.au