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Semin Thromb Hemost 2009; 35(1): 104-110
DOI: 10.1055/s-0029-1214153
© Thieme Medical Publishers

Assessment of Thrombin Generation: Useful or Hype?

Murray Adams1
  • 1Senior Lecturer, School of Human Life Sciences, University of Tasmania, Tasmania, Australia
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Publication History

Publication Date:
23 March 2009 (online)

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ABSTRACT

Thrombin plays an important role in hemostasis through its multiple functions across blood coagulation, platelet activation, and fibrinolysis. The measurement of thrombin generation is therefore viewed as a potentially useful test that could be applied to the screening, monitoring, and/or diagnosis of hemostatic abnormalities. Indeed, advances in thrombin generation assays have created significant interest and debate as to whether they may provide a more physiologically relevant testing system than do traditional coagulation tests. A variety of thrombin generation assays, including commercially available systems, have been investigated for their correlation with hypocoagulable and hypercoagulable states. Although there is an extensive body of literature that has investigated the application of thrombin generation assays, some limitations remain. These include poor standardization of reagents and methods and a lack of large prospective studies that demonstrate clear relationships between thrombin generation with bleeding and thrombosis phenotypes, as well as with monitoring anticoagulation. Whether thrombin generation assays become more “useful” than “hype” will require well-designed, large, prospective multicenter trials using standardized methods.

KEYWORDS

Thrombin generation assays - hemostasis - laboratory testing - thrombosis - bleeding

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Murray AdamsPh.D. M.A.I.M.S. 

School of Human Life Sciences, University of Tasmania

Tasmania 7250, Australia

Email: Murray.Adams@utas.edu.au