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Exp Clin Endocrinol Diabetes 2009; 117(9): 519-521
DOI: 10.1055/s-0029-1216351
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Proline 12 Alanine Substitution in the PPARγ2 Gene is Associated With Increased Extent of Coronary Artery Disease in Men

J. G. Schneider 1 [*] , S. Schiekofer 2 [*] , M. von Eynatten 3 , P. Schlimmer 4 , K. A. Dugi 3
  • 1Department of Medicine, Washington University in St. Louis, USA
  • 2Department of Medicine, Saarland University School of Medicine, Homburg/Saar, Germany
  • 3Department of Medicine I, Ruprecht-Karls-University of Heidelberg, Germany
  • 4Department of Medicine, Saarland University Academic Teaching Hospital at Merzig/Saar, Germany
Further Information

Publication History

received 19.02.2009 first decision 11.03.2009

accepted 11.03.2009

Publication Date:
17 June 2009 (online)

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Abstract

Objective: To determine whether there is an independent association between the Pro12Ala polymorphism in the peroxisome proliferator-activated-receptor γ2 (PPARγ2)-gene and the extent of coronary artery disease in men.

Research Design and Methods: We determined the Pro12Ala polymorphism in the PPARγ2 gene in 240 male patients undergoing elective coronary angiograpy, and quantitated the degree of CAD by evaluating the extent-score which better correlates with known risk factors than other measures of CAD.

Results: The presence of the 12Ala allele was significantly associated with higher CAD extent (r=0.27, p<0.01). CAD extent was also correlated with the extent of insulin resistance (HOMA, r=0.22, p<0.01), and age (r=0.16, p<0.05). Multivariate analysis revealed an independent association between the 12Ala allele PPARγ2 with extent-score (β=0.32, p<0.01).

Conclusions: The 12Ala allele in PPARγ2 correlates with a significantly increased CAD extent in men, which suggest that lower activity of the transcription factor PPARγ2 is associated with more severe CAD.

Key words

coronary artery disease - cardiovascular incidences - coronary syndrome - receptors - signal transduction

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1 Both authors contributed equally

Correspondence

J. G. SchneiderMD 

Washington University School of Medicine

Department of Internal Medicine

Campus Box 8069

St. Louis

MO 63110

USA

Phone: +1/314/454 89 73

Fax: +1/314/454 89 79

Email: js@mailbox-js.de