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Synthesis 2009(9): 1564-1572
DOI: 10.1055/s-0029-1216636
DOI: 10.1055/s-0029-1216636
SPECIALTOPIC
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Conjugate Addition of N-Heterocycles to α,β-Unsaturated Ketones Catalyzed by Chiral Primary Amines
Further Information
Publication History
Received
29 January 2009
Publication Date:
14 April 2009 (online)
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Abstract
A new organocatalytic enantioselective conjugate addition reaction of nitrogen-centered heterocycles with α,β-unsaturated ketones has been developed. Promoted by a chiral cinchona alkaloid derived primary amine, the reaction affords the adducts in moderate to high enantioselectivities.
Key words
primary amines - N-heterocycles - enones - conjugate addition - catalysis