A simple and efficient route for the synthesis of biaryl sulfides
have been developed in aqueous medium under base- and catalyst-free
conditions. A wide variety of heteroaryl halides and thiols underwent
SNAr reaction to provide diaryl sulfides in good to excellent
yields. The remarkable key features of the reaction include the
use of water as an inexpensive and environmentally benign reaction
medium, absence of any additional reagent or catalyst, and easy
isolation of the products.
heteroaryl halides
- thiophenol - SNAr reaction - water - 2-thiopyridines
