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Synthesis 2009(14): 2413-2417
DOI: 10.1055/s-0029-1216833
DOI: 10.1055/s-0029-1216833
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Highly Enantioselective Synthesis of Heteroaromatic Alcohols Catalyzed by Chiral Diaminodiphosphine-Ruthenium(II) Complexes
Further Information
Received
12 February 2009
Publication Date:
27 May 2009 (online)
Publication History
Publication Date:
27 May 2009 (online)
Abstract
Chiral diaminodiphosphine-ruthenium(II) complexes were found to be excellent catalysts for the asymmetric transfer hydrogenation of heteroaromatic ketones in propan-2-ol. In the presence of potassium hydroxide, the enantioselective reduction of heteroaromatic ketones proceeded smoothly to give chiral alcohols with excellent enantiomeric excess (up to 97% ee) under mild conditions without reduction of the heterocycle.
Key words
asymmetric - transfer hydrogenation - catalysis - heteroaromatic ketones - heteroaromatic alcohols
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