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Synthesis 2010(1): 57-62
DOI: 10.1055/s-0029-1217091
DOI: 10.1055/s-0029-1217091
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Tin(II) Compounds as Catalysts for the Kabachnik-Fields Reaction under Solvent-Free Conditions: Facile Synthesis of α-Aminophosphonates
Further Information
Received
13 July 2009
Publication Date:
26 October 2009 (online)
Publication History
Publication Date:
26 October 2009 (online)
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Abstract
In the presence of a catalytic amount of tin(II) salts, the three-component Kabachnik-Fields reaction involving aldehydes, amines, and diethyl phosphite proceeded smoothly to afford the corresponding α-aminophosphonates in good to high yields. These reactions were carried out under solvent-free conditions.
Key words
α-aminophosphonates - catalysis - imines - Lewis acids - solvent-free
- 1
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References
Lewis acids such as SnCl2 may not be necessary in the formation of aminophosphonate 3f, which involves piperidine, a secondary aliphatic amine. We are currently investigating the synthesis of α-aminophosphonates from secondary aliphatic amines.