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Synthesis 2010(4): 689-693  
DOI: 10.1055/s-0029-1218597
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Novel N,3-Substituted 3H-[1,2,3]Triazolo[4,5-d]pyrimidin-5-amines

Finn K. Hansen, Detlef Geffken*
Institute of Pharmacy, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany
Fax: +49(40)428386573; e-Mail: geffken@chemie.uni-hamburg.de;
Further Information

Publication History

Received 1 September 2009
Publication Date:
11 December 2009 (online)

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Abstract

Novel N,3-substituted 3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amines were prepared by an expedient method starting from 2-chloro-5-nitropyrimidin-4-yl thiocyanate via N²,N4-substituted 5-nitropyrimidine-2,4-diamines.

Key words

triazolopyrimidines - 5-nitropyrimidine-2,4-diamines - cyclization - hydrogenation - nucleophilic aromatic substitution

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