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Synthesis 2010(6): 1046-1052
DOI: 10.1055/s-0029-1218629
DOI: 10.1055/s-0029-1218629
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Nucleoside Conjugates as Potential Inhibitors of Glycogen Phosphorylase
Further Information
Received
9 November 2009
Publication Date:
04 January 2010 (online)
Publication History
Publication Date:
04 January 2010 (online)
Abstract
Click chemistry has been successfully used for the synthesis of novel nucleoside conjugates between uridine and N-acetylglucosamine or oleanolic acid derivatives. These molecules displayed micromolar inhibition towards glycogen phosphorylase.
Key words
bioorganic chemistry - carbohydrates - click chemistry - inhibitors - nucleosides
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