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Synthesis 2010(12): 1989-1991  
DOI: 10.1055/s-0029-1218749
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Simple and Efficient Synthesis of the Antimigraine Drug Lomerizine

A. Venkat Narsaiah*, J. Kranthi Kumar
Organic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500007, India
Fax: +91(40)27160387; e-Mail: vnakkirala2001@yahoo.com;
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Publication History

Received 24 February 2010
Publication Date:
19 April 2010 (online)

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Abstract

The synthesis of the antimigraine drug 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine has been carried out in very good yields. The five-step synthesis started from bis(4-fluorophenyl)methanone. This route can be applied for large-scale preparation of lomerizine.

Key words

keto reduction - calcium chloride - trimethoxybenzyl bromide - piperazine

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