Abstract
N -Methylisoxazolidines are formed
in good yields and high regio-, diastereo- and enantioselectivity
via asymmetric 1,3-dipolar cycloaddition of nitrones with enals
catalyzed by a chiral ruthenium Lewis acid. Electronic effects in
the dipole are the key to activation of these substrates for efficient
catalysis.
Key words
asymmetric catalysis - Lewis acid - ruthenium -
N -methyl nitrones - 1,3-dipolar
cycloaddition
References
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