Preparation and N-Alkylation of 4-Aryl-1,2,4-triazoles

Abstract

Heating of N,N-dimethylformamide azine dihydrochloride {N′-[(dimethylamino)methylene]-N,N-dimethylhydrazonoform­amide dihydrochloride} with anilines in the absence of a solvent gave a range of 4-aryl-1,2,4-triazoles by direct transamination. Ortho-substituents were tolerated. Some triazoles were converted into symmetrically and nonsymmetrically substituted bistriazolium salts, one of which was converted into a dicopper complex.

Key words

aminations - cyclizations - heterocycles - alkylations - triazoles

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