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Synthesis 2010(13): 2297-2307
DOI: 10.1055/s-0029-1218800
DOI: 10.1055/s-0029-1218800
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Gold Catalysis: Desymmetrization in the Furan-Yne Reaction
Further Information
Received
5 May 2010
Publication Date:
27 May 2010 (online)
Publication History
Publication Date:
27 May 2010 (online)
Abstract
A series of seven symmetric difuryl-diynes were synthesized by a route delivering an anti-configurated product as the major product. The gold-catalyzed conversion of the individual anti- and syn-diastereomers was investigated. The anti-diastereomer in a desymmetrization reaction chemoselectively delivered dihydroindenediols with a furyl and a 2-oxopropyl side chain. The syn-diastereomer was completely converted into oligomeric/polymeric material. Thus, it was not necessary to separate the minor amount of the syn-diastereomers from the product mixtures in order to isolate the dihydroindenediols.
Key words
alkynes - alcohols - furans - gold - homogeneous catalysis - ketones
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