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Synlett 2010(5): 787-789
DOI: 10.1055/s-0029-1219353
DOI: 10.1055/s-0029-1219353
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Water-Soluble Phosphinophenol for Traceless Staudinger Ligation
Further Information
Received
6 December 2009
Publication Date:
25 January 2010 (online)
Publication History
Publication Date:
25 January 2010 (online)
Abstract
The traceless Staudinger ligation can be mediated in water without organic co-solvents if charged groups render the phenylphosphine reagent water soluble. Here the synthesis of a new water-soluble phosphine is presented based on a diphenylphosphinophenol reagent. Staudinger ligation with this reagent and azido glycine amide showed conversion of 77%.
Key words
amide - phenol - Staudinger ligation - conjugation - phosphine
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