A Simple Route Toward New Clomiphene Metabolites

Abstract

A new clomiphene metabolite, extremely useful for doping analysis, was synthesized in 19% overall yield. The approach involved a Grignard reaction via a N-acylbenzotriazole intermediate to afford a key aromatic ketone and a HWE reaction. Both stereo­isomers were separated and identified.

Key words

clomiphene - Grignard reactions - N-acylbenzotriazole - olefination - drugs

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