Efficient Suzuki and Stille
Reactions for Regioselective Strategies of Incorporation
of the 1,3-Oxazole Heterocycle: Mild Desulfonylation for the Synthesis
of C-4 and C-5 Monosubstituted Oxazoles

David R. Williams; Liangfeng Fu

doi:10.1055/s-0029-1220128

LETTER

Efficient Suzuki and Stille Reactions for Regioselective Strategies of Incorporation of the 1,3-Oxazole Heterocycle: Mild Desulfonylation for the Synthesis of C-4 and C-5 Monosubstituted Oxazoles

David R. Williams*, Liangfeng Fu
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405-7102, USA
Fax: +1(812)8558300; e-Mail: williamd@indiana.edu;

Abstract

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Abstract

Suzuki and Stille cross-coupling reactions are surveyed for site-selective C-4 and C-5 elaboration of 2-(phenylsulfonyl)-1,3-oxazole derivatives. Conditions for mild reductive desulfonylations provide for direct incorporation of the intact oxazole heterocycle through bonding at C-4 and C-5.

Key words

cross-coupling reactions - arylation - alkenylation - reductive desulfonylation

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References

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