Direkte Renininhibition: ein neues und viel versprechendes Wirkprinzip in der Herzinsuffizienztherapie?

Schlüsselwörter

Renininhibition - Herzinsuffizienz - Aliskiren

Keywords

renin inhibition - heart failure - aliskiren

Literatur

• 1 Alderman M H, Madhavan S, Ooi W L, Cohen H, Sealey J E, Laragh J H. Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension.  N Engl J Med. 1991;  324 1098-1104
• 2 Brown M J. Aliskiren.  Circulation. 2008;  118 773-784
• 3 Burnier M, Brunner H R. Angiotensin II receptor antagonists.  Lancet. 2000;  355 637-645
• 4 Mueller D N, Luft F C. Renin receptor blockade: a better strategy for renal protection than Renin-Angiotensin system inhibition?.  Current Hypertension Rep. 2008;  10 405-409
• 5 Latini R, Masson S, Anand I. et al . The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT.  Eur Heart J. 2004;  25 292-299
• 6 Luft F C. Renin and its putative receptor remain enigmas.  J Am Soc Nephrol. 2007;  18 1989-1892
• 7 McMurray J, Bertram P, Latini R. et al . Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure.  Circulation Heart Failure. 2008;  1 17-24
• 8 Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer J D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.  J Clin Invest. 2002;  109 1417-1427
• 9 Parving H H, Persson F, Lewis J B, Lewis E J, Hollenberg N K. Aliskiren combined with losartan in type 2 diabetes and nephropathy.  N Engl J Med. 2008;  358 2433-2446
• 10 Parving H H, Lewis J B, Lewis E J, Hollenberg N K. AVOID Aliskiren in the Evaluation of Proteinuria in Diabetes. California, USA; American Society of Nephrology Renal Week Congress in San Francisco 2007 Poster SA-P01051
• 11 Pfeffer M A, McMurray J J, Velazquez E J. et al . Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both.  N Engl J Med. 2003;  349 1893-1906
• 12 Skeggs L T, Kahn J R, Lentz K, Shumway N P. The preparation, purification, and amino acid sequence of a polypeptide renin substrate.  J Exp Med. 1957;  106 439-453
• 13 Solomen S D, Appelbaum E, Manning W. et al . Effect o fthe direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy.  Circulation. 2009;  119 530-537
• 14 Staessen J A, Li Y, Richart T. Oral renin inhibitors.  Lancet. 2006;  368 1449-1456
• 15 Werner C, Baumhakel M, Teo K K. et al . RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection.  Clin Res Cardiol. 2008;  97 418-431