Die Bedeutung des Gehirns für die Regulation von Energie- und Glukosestoffwechsel

Schlüsselwörter

Adipositas - Typ-2-Diabetes - Gehirn - Energiehaushalt

Keywords

obesity - type 2 diabetes - brain - energy homeostasis

Literatur

• 1 Gropp E, Shanabrough M, Borok E, Xu A W, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A. et al . Agouti-related peptide-expressing neurons are mandatory for feeding.  Nat Neurosci. 2005;  8 1289-1291
• 2 Horvath T L. Synaptic plasticity in energy balance regulation.  Obesity (Silver Spring). 2006;  14 Suppl 5 228S-233S
• 3 Konner A C, Janoschek R, Plum L, Jordan S D, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh G S. et al . Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production.  Cell Metab. 2007;  5 438-449
• 4 Lam T K, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, Schwartz G J, Rossetti L. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis.  Nature Med. 2005;  11 320-327
• 5 Loftus T M, Jaworsky D E, Frehywot G L, Townsend C A, Ronnett G V, Lane M D, Kuhajda F P. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors.  Science. 2000;  288 2379-2381
• 6 Mizuno T M, Kleopoulos S P, Bergen H T, Roberts J L, Priest C A, Mobbs C V. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin.  Diabetes. 1998;  47 294-297
• 7 Tschop M, Smiley D L, Heiman M L. Ghrelin induces adiposity in rodents.  Nature. 2000;  407 908-913