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DOI: 10.1055/s-0029-1234058
© Georg Thieme Verlag KG Stuttgart · New York
Nandrolone Inhibits VEGF mRNA in Rat Muscle
Publication History
accepted after revision June 28, 2009
Publication Date:
14 October 2009 (online)
Abstract
Vascular endothelial growth factor (VEGF) is a key compound for induction of angiogenesis in both physiological and pathological conditions. The aim of this study was to investigate the effect of androgenic-anabolic steroids (AAS) administration on VEGF mRNA expression in the rat soleus muscle after jumping training. Wistar rats were grouped into: sedentary (S); nandrolone decanoate-treated sedentary (AAS); trained without AAS (T) and trained and treated with AAS (AAST). Exercised groups performed a 7-weeks water-jumping program. Animals killed immediately after the last exercise bout showed significantly increased VEGF mRNA expression; however, the AAS treatment completely inhibited this effect. These results suggest that the AAS may be strongly prejudicial to muscle remodeling and performance at least partially due to an impaired angiogenesis.
Key words
angiogenic factor - androgenic-anabolic steroid - skeletal muscle - mechanical load exercise
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Correspondence
Prof. R. Marqueti
Universidade Federal de São Carlos
Ciências Fisiológicas
Washington Luiz
Km 235
Monjolinho
13565905
São Carlos
Brazil
Phone: 551633518333
Fax: 551633518327
Email: marqueti@gmail.com