ABSTRACT
We investigated whether the presence of symptoms predicts the timing of subsequent spontaneous preterm birth in a cohort of women with cervical length (CL) <1.5 cm. A retrospective cohort study was conducted that included patients from 23 to 28 weeks' gestation with a CL <1.5 cm on routine ultrasound. Two groups were defined on the basis of presenting symptoms at the time of the ultrasound examination: asymptomatic patients and those with symptoms of preterm labor. The incidence of delivery within 2 weeks was determined for both groups. A total of 88 patients with CL <1.5 cm were identified from an ultrasound database. There were 52 patients with CL <1.5 cm and no symptoms. Of these, 1 (1.9%) delivered within 2 weeks. The remaining 36 patients had a CL <1.5 cm and symptoms of preterm labor. Of these, 11 (30.6%) delivered within 2 weeks (relative risk 15.9, 95% confidence interval 2.1 to 118). Premature cervical shortening at 23 to 28 weeks, in the absence of symptoms of preterm labor, is rarely associated with preterm delivery within 2 weeks. Following those patients clinically may prevent prolonged hospitalization and allow steroid administration closer to the date of delivery.
KEYWORDS
Prematurity - preterm birth - preterm labor - ultrasound - short cervix
REFERENCES
-
1 Institute of Medicine .Preterm Birth: Causes, Consequences, and Prevention. Washington, DC; National Academics Press 2006
-
2
Berkowitz G S, Blackmore-Prince C, Lapinski R H, Savitz D A.
Risk factors for preterm birth subtypes.
Epidemiology.
1998;
9
279-285
-
3
McElrath T F, Hecht J L, Dammann O ELGAN Study Investigators et al.
Pregnancy disorders that lead to delivery before the 28th week of gestation: an epidemiologic approach to classification.
Am J Epidemiol.
2008;
168
980-989
-
4
Mercer B M.
Preterm premature rupture of the membranes.
Obstet Gynecol.
2003;
101
178-193
-
5
Saigal S, Doyle L W.
An overview of mortality and sequelae of preterm birth from infancy to adulthood.
Lancet.
2008;
371
261-269
-
6
Heath V C, Southall T R, Souka A P, Elisseou A, Nicolaides K H.
Cervical length at 23 weeks of gestation: prediction of spontaneous preterm delivery.
Ultrasound Obstet Gynecol.
1998;
12
312-317
-
7
Goldenberg R L, Iams J D, Mercer B M National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network et al.
What we have learned about the predictors of preterm birth.
Semin Perinatol.
2003;
27
185-193
-
8
Fox N S, Jean-Pierre C, Predanic M, Chasen S T.
Does hospitalization prevent preterm delivery in the patient with a short cervix?.
Am J Perinatol.
2007;
24
49-53
-
9
Crowley P A.
Antenatal corticosteroid therapy: a meta-analysis of the randomized trials, 1972 to 1994.
Am J Obstet Gynecol.
1995;
173
322-335
-
10
Crowley P.
Antenatal corticosteroids—current thinking.
BJOG.
2003;
110(suppl 20)
77-78
-
11
Iams J D.
Prediction and early detection of preterm labor.
Obstet Gynecol.
2003;
101
402-412
-
12
Alfirevic Z.
Cerclage: we all know how to do it but can't agree when to do it.
Obstet Gynecol.
2006;
107(2 Pt 1)
219-220
-
13
Leitich H, Brunbauer M, Kaider A, Egarter C, Husslein P.
Cervical length and dilatation of the internal cervical os detected by vaginal ultrasonography as markers for preterm delivery: a systematic review.
Am J Obstet Gynecol.
1999;
181
1465-1472
-
14
Gomez R, Galasso M, Romero R et al..
Ultrasonographic examination of the uterine cervix is better than cervical digital examination as a predictor of the likelihood of premature delivery in patients with preterm labor and intact membranes.
Am J Obstet Gynecol.
1994;
171
956-964
-
15
Iams J D, Goldenberg R L, Meis P J National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network et al.
The length of the cervix and the risk of spontaneous premature delivery.
N Engl J Med.
1996;
334
567-572
-
16
Gomez R, Romero R, Medina L et al..
Cervicovaginal fibronectin improves the prediction of preterm delivery based on sonographic cervical length in patients with preterm uterine contractions and intact membranes.
Am J Obstet Gynecol.
2005;
192
350-359
-
17
Smith R.
Parturition.
N Engl J Med.
2007;
356
271-283
-
18
House M, Socrate S.
The cervix as a biomechanical structure.
Ultrasound Obstet Gynecol.
2006;
28
745-749
-
19
Stys S J, Clewell W H, Meschia G.
Changes in cervical compliance at parturition independent of uterine activity.
Am J Obstet Gynecol.
1978;
130
414-418
Fadi G MirzaM.D.
Clinical Fellow in Maternal-Fetal Medicine, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Medical Center
622 West 168th Street, New York, NY 10032
eMail: fgm2107@columbia.edu