Yomogin Inhibits the Degranulation of Mast Cells and the Production of the Nitric Oxide in Activated RAW 264.7 Cells

Abstract

Yomogin (1), an eudesmane sesquiterpene isolated from Artemisia princeps, was tested for the effects on the degranulation process of cultured mast cells and on the nitric oxide production in LPS-activated murine macrophages. It demonstrated a significant inhibition on the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner (IC₅₀ value, 50µM) and also exhibited a potent inhibition on the nitric oxide production from the activated RAW264.7 cells (IC₅₀ value, 3µM).

References

• 1 Choi S H, Kim Y R, Lim D K, Bae E O. Yakak Hoiji 1992 36: 140-149
• 2 Choi O H, Kim J H, Kinet J P. Nature 1996 380: 634-636
• 3 Cheong H, Choi E J, Yoo G S, Kim K M, Ryu S Y. Planta Med 1998 64: 577-578
• 4 Fisher B, Schmutzler W. Arzneimittelforsch 1981 31: 1193-5
• 5 Oshima H, Bartsch H. Mutat Res 1994 305: 253-264
• 6 Walker G, Pfeilschifter J, Kunz D. J Biol Chem 1997 272: 16679-16687
• 7 Ryu J H, Lee H J, Jeong Y S, Ryu S Y, Han Y N. Arch Pharm Res 1998 21: 481-484
• 8 Jakupovic J, Schuster F, Bohlmann F, Dillon M O. Phytochemistry 1988 27: 1113-1120