Early Versus Delayed Minimal Enteral Feeding and Risk for Necrotizing Enterocolitis in Preterm Growth-Restricted Infants with Abnormal Antenatal Doppler Results

Paraskevi Karagianni; Despina D Briana; George Mitsiakos; Anestis Elias; Theodoros Theodoridis; Elias Chatziioannidis; Maria Kyriakidou; Nikolaos Nikolaidis

doi:10.1055/s-0029-1243310

American Journal of Perinatology, Table of Contents

Am J Perinatol 2010; 27(5): 367-373
DOI: 10.1055/s-0029-1243310

Early Versus Delayed Minimal Enteral Feeding and Risk for Necrotizing Enterocolitis in Preterm Growth-Restricted Infants with Abnormal Antenatal Doppler Results

Paraskevi Karagianni¹ , Despina D. Briana² , George Mitsiakos¹ , Anestis Elias¹ , Theodoros Theodoridis³ , Elias Chatziioannidis¹ , Maria Kyriakidou¹ , Nikolaos Nikolaidis¹

¹2nd NICU and Neonatology Department, Aristotle University of Thessaloniki, G.P.N. Papageorgiou, Thessaloniki, Greece
²Honorary Clinical Fellow, Newborn Unit, King's College Hospital, London, United Kingdom
³1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, G.P.N. Papageorgiou, Thessaloniki, Greece

Abstract

ABSTRACT

We studied the effect of early (≤5 days) versus delayed (≥6 days) initiation of minimal enteral feeding (MEF) on the incidence of necrotizing enterocolitis (NEC) and feeding intolerance in preterm infants with intrauterine growth restriction (IUGR) and abnormal antenatal Doppler results. We performed a randomized, nonblinded pilot trial of infants receiving early or delayed MEF in addition to parenteral feeding within 48 hours of life. Demographic data, maternal preeclampsia, antenatal steroid exposure, Doppler studies, as well as cases of NEC and feeding intolerance were all recorded. Of the 84 infants enrolled, 81 completed the study: 40 received early (median age: 2 days, range: 1 to 5 days) and 41 delayed (median age: 7 days, range: 6 to 14 days) MEF. The incidence of NEC and feeding intolerance was not significantly different between groups (p = 0.353 and p = 0.533, respectively). Birth weight was an independent risk factor for NEC in both groups. Early MEF of preterm infants with IUGR and abnormal antenatal Doppler results may not have a significant effect on the incidence of NEC or feeding intolerance. Furthermore, birth weight seems to be an independent risk factor for the development of NEC, irrespectively of the timing of MEF introduction.

KEYWORDS

Prematurity - intrauterine growth restriction - necrotizing enterocolitis - minimal enteral feeding - Doppler

Full Text

References

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Paraskevi KaragianniM.D.

2nd NICU and Neonatology Department, G.P.N. Papageorgiou, Ring Road, Nea Efkarpia

56403 Thessaloniki, Greece

Email: karagpar@med.auth.gr