Aktuelle molekular-zytogenetische Aspekte zur Pathologie und Differenzierung von extranodalen Marginalzonen B-Zell-Lymphomen vom MALT-Typ und gastrointestinalen diffusen großzelligen B-Zell-Lymphomen

Zusammenfassung

Das Marginalzonen B-Zell-Lymphom vom MALT-Typ (MZBL, MT) ist ein häufig im Magen lokalisiertes, niedrig malignes B-Zell-Lymphom mit typischer Morphologie und Zytogenetik. Daneben existieren das gastrointestinale diffuse großzellige B-Zell-Lymphom (DLBCL) und Kompositlymphome (ComL) mit koexistenter groß- und kleinzelliger Zytologie, die aufgrund dessen ein faszinierendes Modell hinsichtlich der Lymphomprogression darstellen. Im vorliegenden Review werden die wichtigsten aktuellen Aspekte zur molekularen Charakterisierung der MZBL, MT und der gastrointestinalen DLBCL sowie einer Relation dieser Lymphomentitäten untereinander zusammengefasst, die sie klar von den nodalen DLBCL abgrenzen.

Abstract

The marginal zone B-cell lymphoma, MALT-type (MZBL, MT) is a low-grade B-cell lymphoma which is predominantly localised in the stomach with a typical morphology and cytogenetic pattern. The coexistence of a diffuse large B-cell lymphoma (DLBCL) with an MZBL, MT in the gastrointestinal tract is defined as a composite lymphoma (ComL) and represents a fascinating model of lymphoma progression. In this review we focus on current aspects regarding the molecular characterisation of MZBL, MT and gastrointestinal DLBCL and their mutual relationships.

MALT-Lymphom - gastrales DLBCL - Molekularbiologie

MALT lymphom - gastric DLBCL - molecular biology

Literatur

• 1 d’Amore F, Christensen B E, Brincker H et al. Clinicopathological features and prognostic factors in extranodal non-Hodgkin lymphomas. Danish LYFO Study Group.  Eur J Cancer. 1991;  27 1201-1208
• 2 Zheng T, Mayne S T, Boyle P et al. Epidemiology of non-Hodgkin lymphoma in Connecticut. 1935 – 1988.  Cancer. 1992;  70 840-849
• 3 A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. The Non-Hodgkin’s Lymphoma Classification Project.  Blood. 1997;  89 3909-3918
• 4 Newton R, Ferlay J, Beral V et al. The epidemiology of non-Hodgkin’s lymphoma: comparison of nodal and extra-nodal sites.  Int J Cancer. 1997;  72 923-930
• 5 Hussell T, Isaacson P G, Crabtree J E et al. The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori.  Lancet. 1993;  342 571-574
• 6 Greiner A, Marx A, Heesemann J et al. Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis.  Lab Invest. 1994;  70 572-578
• 7 Isaacson P G, Du M Q. MALT lymphoma: from morphology to molecules.  Nat Rev Cancer. 2004;  4 644-653
• 8 Isaacson P G, Chott A, Nakamura S et al. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). World Health Organization Classification of Tumours of Hematopoietic and Lymphoid Tisues.  Swerdlow SH Campo E Harris NL et al.. 2008;  214-217
• 9 Wotherspoon A C, Ortiz-Hidalgo C, Falzon M R et al. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma.  Lancet. 1991;  338 1175-1176
• 10 Karat D, O’Hanlon D M, Hayes N et al. Prospective study of Helicobacter pylori infection in primary gastric lymphoma.  Br J Surg. 1995;  82 1369-1370
• 11 Bouzourene H, Haefliger T, Delacretaz F et al. The role of Helicobacter pylori in primary gastric MALT lymphoma.  Histopathology. 1999;  34 118-123
• 12 Lecuit M, Abachin E, Martin A et al. Immunoproliferative small intestinal disease associated with Campylobacter jejuni.  N Engl J Med. 2004;  350 239-248
• 13 Wundisch T, Mosch C, Neubauer A et al. Helicobacter pylori eradication in gastric mucosa-associated lymphoid tissue lymphoma: Results of a 196-patient series.  Leuk Lymphoma. 2006;  47 2110-2114
• 14 Bayerdorffer E, Neubauer A, Rudolph B et al. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group.  Lancet. 1995;  345 1591-1594
• 15 Du M Q, Isaccson P G. Gastric MALT lymphoma: from aetiology to treatment.  Lancet Oncol. 2002;  3 97-104
• 16 Fischbach W, Malfertheiner P, Hoffmann J C et al. S3-guideline ”helicobacter pylori and gastroduodenal ulcer disease” of the German society for digestive and metabolic diseases (DGVS) in cooperation with the German society for hygiene and microbiology, society for pediatric gastroenterology and nutrition e. V., German society for rheumatology, AWMF-registration-no. 021 / 001.  Z Gastroenterol. 2009;  47 1230-1263
• 17 Koch P, Probst A, Berdel W E et al. Treatment results in localized primary gastric lymphoma: data of patients registered within the German multicenter study (GIT NHL 02 / 96).  J Clin Oncol. 2005;  23 7050-7059
• 18 Hussell T, Isaacson P G, Crabtree J E et al. Helicobacter pylori-specific tumour-infiltrating T cells provide contact dependent help for the growth of malignant B cells in low-grade gastric lymphoma of mucosa-associated lymphoid tissue.  J Pathol. 1996;  178 122-127
• 19 Nakamura S, Aoyagi K, Furuse M et al. B-cell monoclonality precedes the development of gastric MALT lymphoma in Helicobacter pylori-associated chronic gastritis.  Am J Pathol. 1998;  152 1271-1279
• 20 Ott G, Katzenberger T, Greiner A et al. The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin’s lymphomas of the mucosa-associated lymphoid tissue (MALT-) type.  Cancer Res. 1997;  57 3944-3948
• 21 Auer I A, Gascoyne R D, Connors J M et al. t(11;18)(q21;q21) is the most common translocation in MALT lymphomas.  Ann Oncol. 1997;  8 979-985
• 22 Remstein E D, James C D, Kurtin P J. Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas.  Am J Pathol. 2000;  156 1183-1188
• 23 Ye H, Liu H, Attygalle A et al. Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma.  Blood. 2003;  102 1012-1018
• 24 Remstein E D, Kurtin P J, James C D et al. Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways.  Am J Pathol. 2002;  161 63-71
• 25 Uren A G, O’Rourke K, Aravind L A et al. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.  Mol Cell. 2000;  6 961-967
• 26 Lucas P C, Yonezumi M, Inohara N et al. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway.  J Biol Chem. 2001;  276 19 012-19 019
• 27 Liu H, Ye H, Ruskone-Fourmestraux A et al. T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication.  Gastroenterology. 2002;  122 1286-1294
• 28 Liu H, Ye H, Dogan A et al. T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10.  Blood. 2001;  98 1182-1187
• 29 Streubel B, Simonitsch-Klupp I, Mullauer L et al. Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites.  Leukemia. 2004;  18 1722-1726
• 30 Du M, Peng H, Singh N et al. The accumulation of p53 abnormalities is associated with progression of mucosa-associated lymphoid tissue lymphoma.  Blood. 1995;  86 4587-4593
• 31 Neumeister P, Hoefler G, Beham-Schmid C et al. Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas.  Gastroenterology. 1997;  112 1871-1875
• 32 Barth T F, Bentz M, Leithauser F et al. Molecular-cytogenetic comparison of mucosa-associated marginal zone B-cell lymphoma and large B-cell lymphoma arising in the gastro-intestinal tract. Genes Chromosomes.  Cancer. 2001;  31 316-325
• 33 Zhou Y, Ye H, Martin-Subero J I et al. Distinct comparative genomic hybridisation profiles in gastric mucosa-associated lymphoid tissue lymphomas with and without t(11;18)(q21;q21).  Br J Haematol. 2006;  133 35-42
• 34 Barth T F, Bentz M, Leithauser F et al. Pathogenic complexity of gastric B-cell lymphoma.  Blood. 2002;  100 1095-1096
• 35 Cabras A D, Candidus S, Fend F et al. Biclonality of gastric lymphomas.  Lab Invest. 2001;  81 961-967
• 36 Barth T F, Dohner H, Werner C A et al. Characteristic pattern of chromosomal gains and losses in primary large B-cell lymphomas of the gastrointestinal tract.  Blood. 1998;  91 4321-4330
• 37 Streubel B, Lamprecht A, Dierlamm J et al. T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma.  Blood. 2003;  101 2335-2339
• 38 Ye H, Gong L, Liu H et al. MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression.  J Pathol. 2005;  205 293-301
• 39 Sanchez-Izquierdo D, Buchonnet G, Siebert R et al. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma.  Blood. 2003;  101 4539-4546
• 40 Dierlamm J, Murga Penas E M, Bentink S et al. Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma.  Haematologica. 2008;  93 688-696
• 41 Willis T G, Jadayel D M, Du M Q et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.  Cell. 1999;  96 35-45
• 42 Zhang Q, Siebert R, Yan M et al. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).  Nat Genet. 1999;  22 63-68
• 43 Ye H, Gong L, Liu H et al. Strong BCL10 nuclear expression identifies gastric MALT lymphomas that do not respond to H pylori eradication.  Gut. 2006;  55 137-138
• 44 Thome MCARMA1, BCL-10 and MALT1 in lymphocyte development and activation.  Nat Rev Immunol. 2004;  4 348-359
• 45 Dong G, Liu C, Ye H et al. BCL10 nuclear expression and t(11;18)(q21;q21) indicate nonresponsiveness to Helicobacter pylori eradication of Chinese primary gastric MALT lymphoma.  Int J Hematol. 2008;  88 516-523
• 46 Ohshima K, Kawasaki C, Muta H et al. CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD 10 is a marker of improved prognosis.  Histopathology. 2001;  39 156-162
• 47 Streubel B, Vinatzer U, Lamprecht A et al. T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma.  Leukemia. 2005;  19 652-658
• 48 Wlodarska I, Veyt E, Paepe de P et al. FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations.  Leukemia. 2005;  19 1299-1305
• 49 Fenton J A, Schuuring E, Barrans S L et al. t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma. Genes Chromosomes.  Cancer. 2006;  45 164-168
• 50 Ye H, Remstein E D, Bacon C M et al. Chromosomal translocations involving BCL6 in MALT lymphoma.  Haematologica. 2008;  93 145-146
• 51 Chen Y W, Hu X T, Liang A C et al. High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma.  Blood. 2006;  108 2373-2383
• 52 Remstein E D, Dogan A, Einerson R R et al. The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America.  Am J Surg Pathol. 2006;  30 1546-1553
• 53 Nakamura S, Ye H, Bacon C M et al. Clinical impact of genetic aberrations in gastric MALT lymphoma: a comprehensive analysis using interphase fluorescence in situ hybridisation.  Gut. 2007;  56 1358-1363
• 54 Vinatzer U, Gollinger M, Mullauer L et al. Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.  Clin Cancer Res. 2008;  14 6426-6431
• 55 Nakamura S, Ye H, Bacon C M et al. Translocations involving the immunoglobulin heavy chain gene locus predict better survival in gastric diffuse large B-cell lymphoma.  Clin Cancer Res. 2008;  14 3002-3010
• 56 Barth T F, Barth C A, Kestler H A et al. Transcriptional profiling suggests that secondary and primary large B-cell lymphomas of the gastrointestinal (GI) tract are blastic variants of GI marginal zone lymphoma.  J Pathol. 2007;  211 305-313