Acute Pancreatitis in a Patient with Hypercalcemia due to Tertiary Hyperparathyroidism

J. Stephani; A. S. Akinli; G. von Figura; T. F. E. Barth; T. Weber; B. Hartmann; G. Adler; G. B. von Boyen

doi:10.1055/s-0029-1245981

Zeitschrift für Gastroenterologie, Table of Contents

Z Gastroenterol 2011; 49(9): 1263-1266
DOI: 10.1055/s-0029-1245981

Kasuistik

Acute Pancreatitis in a Patient with Hypercalcemia due to Tertiary Hyperparathyroidism

Akute Pankreatitis bei einem Patienten mit Hypercalcämie infolge eines tertiären HyperparathyreoidismusJ. Stephani¹ , A. S. Akinli¹ , G. von Figura¹ , T. F. E. Barth² , T. Weber³ , B. Hartmann¹ , G. Adler¹ , G. B. von Boyen¹

¹Department of Internal Medicine I, University of Ulm, Germany
²Department of Pathology, University of Ulm, Germany
³Department of General, Visceral, and Transplantation Surgery, University of Ulm, Germany

Abstract

Zusammenfassung

Hypercalcämie gilt als unabhängiger Risikofaktor für die akute Pankreatitis und wird häufig durch eine Nebenschilddrüsenüberfunktion verursacht. In dieser Kasuistik berichten wir über einen 35-jährigen Patienten, der sich 6 Wochen nach Nierentransplantation mit abdominellen Schmerzen in unserer Klinik vorstellte. Mittels Laboranalytik und Ultraschalldiagnostik wurde eine akute Pankreatitis mit Hypercalcämie auf dem Boden eines tertiären Hyperparathyreoidismus diagnostiziert. Nach konservativer Therapie der akuten Pankreatitis erfolgte eine Parathyreoidektomie mit autologer Gewebetransplantation. Dieser Fallbericht präsentiert die akute Pankreatitis als schwerwiegende und außergewöhnliche Komplikation eines tertiären Hyperparathyreoidismus nach Nierentransplantation.

Abstract

Hypercalcemia represents an independent risk factor of acute pancreatitis and can result from hyperfunctioning parathyroid glands. Here, we report on a 35-year-old patient who was admitted to our hospital with abdominal pain six weeks after kidney transplantation. Based on laboratory tests and ultrasound imaging, acute pancreatitis with hypercalcemia due to tertiary hyperparathyroidism was diagnosed. Subsequently, the patient was treated by parathyroidectomy with autologous tissue transplantation. This constellation points to acute pancreatitis as a very rare and severe complication of patients developing tertiary hyperparathyroidism-related hypercalcemia from secondary hyperparathyroidism after kidney transplantation.

Schlüsselwörter

akute Pankreatitis - Hypercalcämie - tertiärer Hyperparathryreoidismus - Nierentransplantation

Key words

acute pancreatitis - hypercalcemia - tertiary hyperparathyroidism - kidney transplantation

Full Text

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Johannes Stephani, MD

Department of Internal Medicine I, University of Ulm

Albert-Einstein-Allee 23

89081 Ulm

Germany

Phone: ++ 49/7 31/50 04 47 18

Fax: ++ 49/7 31/50 04 45 02

Email: johannes.stephani@uniklinik-ulm.de