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Klin Monbl Augenheilkd 2011; 228(2): 98-103
DOI: 10.1055/s-0029-1246078
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Biologische und physikalische Aspekte des Augendrucks

Biological and Physical Aspects of Intraocular PressureH. A. Reitsamer1 , B. Bogner1 , C. Nischler1 , C. Strohmaier1 , W. Radner1 , F. Schroedl1 , 2 , C. Runge1 , A. Trost1 , 3 , J. W. Kiel4
  • 1Augenklinik, PMU/SALK, Salzburg, Österreich
  • 2Anatomie, PMU, Salzburg, Österreich
  • 3Regenerative Medizin, PMU, Salzburg, Österreich
  • 4Augenklinik, UTHSCSA, San Antonio, Texas, USA
Further Information

Publication History

eingereicht: 21.12.2010

angenommen: 25.1.2011

Publication Date:
15 February 2011 (online)

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Zusammenfassung

Das genaue Verständnis der Mechanismen der Augendruckentstehung ist Voraussetzung für die Entwicklung neuer Strategien zur Behandlung von Patienten mit erhöhtem Augendruck oder Glaukom, aber auch, um die pathogenetischen Prozesse bei der Entstehung von Glaukomen und anderen augendruckassoziierten Erkrankung besser zu verstehen. Die vorliegende Arbeit versucht einen alternativen Einblick in die biologischen und physikalischen Aspekte der Augendruckentstehung und Regulation zu geben. Es wird das Druck-Volumen-Modell und das hydraulische Modell des Augendrucks beschrieben und unter anderem auch die Interaktion von Ziliarkörperdurchblutung und Kammerwassersekretion dargelegt. Der in der Vergangenheit weitgehend vernachlässigten Ziliarkörperdurchblutung kommt nach neueren Erkenntnissen möglicherweise auch eine klinisch relevante Bedeutung bei der Anwendung unterschiedlicher Pharmaka und Antiglaukomatosa zu. Ziel der vorliegenden Arbeit ist es daher, die verschiedenen Aspekte in strukturierter Art und Weise verständlich miteinander zu verknüpfen.

Abstract

A thorough understanding of intraocular pressure homeostasis is the biological foundation for the development of new strategies to treat patients with elevated intraocular pressure or glaucoma. However, investigations on the physiology of intraocular pressure homeostasis are also important to gain more comprehensive insights into the pathogenesis of glaucoma and other diseases with associated alterations of intraocular pressure. The present review intends to give alternative insights into the biological and physical aspects of intraocular pressure regulation. The pressure-volume as well as the hydraulic model of intraocular pressure and also the relationship between ciliary blood flow and aqueous humor production, which has moved into the centre of interest because of its possible clinical relevance for glaucoma patients, will be explained. The authors Have attempted to interrelate the different aspects of intraocular pressure genesis and regulation in a comprehensive but understandable way.

Schlüsselwörter

Glaukom - Pharmakologie - Chorioidea

Key words

glaucoma - pharmacology - choroid

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Prof. Dr. Herbert A. Reitsamer

Ophthalmology and Optometry, Paracelsus Medical University

Muellner Hauptstrasse 48

5020 Salzburg

Phone: ++ 43/6 62/4 48 25 84 73

Fax: ++ 43/6 62/44 82 37 03

Email: h.reitsamer@salk.at