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Klin Padiatr 2010; 222(4): 271-272
DOI: 10.1055/s-0030-1248259
Short Communication

© Georg Thieme Verlag KG Stuttgart · New York

Hyperlactic Acidosis as Metabolic Side-Effect of Albuterol and Theophylline in Acute Severe Asthma

Laktatazidose als Komplikation einer Salbutamol- und Theophyllin-Therapie im Rahmen eines akuten AsthmaanfallsA. Kovacevic, B. Schwahn, A. Schuster
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Publication Date:
30 April 2010 (online)

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Abbreviations

BE

base excess

b.i.d.

bis in die

BP

blood pressure

bpm

beats per minute

DPI

dry powder inhaler

FFA

free fatty acids

IV

intravenous

L/P ratio

lactate to pyruvate ratio

MR-proton spectroscopy

magnetic resonance-proton spectroscopy

ref.

reference

tcSO2

transcutaneous oxygen saturation

Hyperlactic acidosis in acute severe asthma has been described repeatedly both during therapy with inhaled or intravenous β2-agonists and as complication after theophylline overdose respectively in rare cases after the usual dose (Creagh-Brown BC et al. Am J Emerg Med 2008; 26: 514.e1–e3; Koh YI et al. Korean J Intern Med 2002; 17: 147–149). But the mechanisms by which these drugs may cause hyperlactatemia are not well understood and a causal relationship is still controversially discussed.