Neonatal Outcomes in Twin Pregnancies Delivered Moderately Preterm, Late Preterm, and Term

Jerrie S Refuerzo; Valerija Momirova; Alan M Peaceman; Anthony Sciscione; Dwight J Rouse; Steve N Caritis; Catherine Y Spong; Michael W Varner; Fergal D Malone; Jay D Iams; Brian M Mercer; John M Thorp; Yoram Sorokin; Marshall W Carpenter; Julie Lo; Margaret Harper

doi:10.1055/s-0030-1248940

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2010; 27(7): 537-542
DOI: 10.1055/s-0030-1248940

Neonatal Outcomes in Twin Pregnancies Delivered Moderately Preterm, Late Preterm, and Term

Jerrie S. Refuerzo¹ , Valerija Momirova² , Alan M. Peaceman³ , Anthony Sciscione⁴ , Dwight J. Rouse⁵ , Steve N. Caritis⁶ , Catherine Y. Spong⁷ , Michael W. Varner⁸ , Fergal D. Malone⁹ , Jay D. Iams¹⁰ , Brian M. Mercer¹¹ , John M. Thorp¹² , Yoram Sorokin¹³ , Marshall W. Carpenter¹⁴ , Julie Lo¹⁵ , Margaret Harper¹⁶ for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network

¹Department of Obstetrics and Gynecology at the University of Texas Health Science Center at Houston, Houston, Texas
²Northwestern University, Chicago, Illinois
³Drexel University, Philadelphia, Pennsylvania
⁴University of Alabama at Birmingham, Birmingham, Alabama
⁵University of Pittsburgh, Pittsburgh, Pennsylvania
⁶University of Utah, Salt Lake City, Utah
⁷Columbia University, New York, New York
⁸The Ohio State University, Columbus, Ohio
⁹Case Western Reserve University, Cleveland, Ohio
¹⁰University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
¹¹Wayne State University, Detroit, Michigan
¹²University of Texas Southwestern Medical Center, Dallas, Texas
¹³Brown University, Providence, Rhode Island
¹⁴Wake Forest University Health Sciences, Winston-Salem, North Carolina
¹⁵The George Washington University Biostatistics Center, Washington, D.C.
¹⁶the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland

Abstract

ABSTRACT

We compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB), and term birth. A secondary analysis of a multicenter, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 32⁰/₇ and 33⁶/₇ weeks and LPTB between 34⁰/₇ and 36⁶/₇ weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonary dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, LPTB 49.8%, and term birth rate 35.7%. The rate of the primary outcome was different between groups: 30.0% for MPTB, 12.8% for LPTB, 0.5% for term birth (p < 0.001). Compared with term neonates, the primary neonatal outcome composite was increased following MPTB (relative risk [RR] 58.5; 95% confidence interval [CI] 11.3 to 1693.0) and LPTB (RR 24.9; 95% CI 4.8 to 732.2). Twin pregnancies born moderately and late preterm encounter higher rates of neonatal morbidities compared with twins born at term.

KEYWORDS

Twin pregnancy - late preterm birth - neonatal morbidities

Volltext

Referenzen

REFERENCES

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Jerrie RefuerzoM.D.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston 6431 Fannin Street

#3.270 Houston, TX 77030

eMail: Jerrie.S.Refuerzo@uth.tmc.edu