Abstract
Two new holostane-type triterpene glycosides, named pentactasides I (1) and II (2), and a new natural product, pentactaside III (3), together with two known glycosides, philinopsides A (4) and B (5), were isolated from the sea cucumber Pentacta quadrangularis. Their structures were elucidated by extensive spectroscopic analysis and chemical
evidences. Compounds 1 and 2 possess the same trisaccharide moiety which is a rare structural feature among naturally
occurring sea cucumber glycosides and has been infrequently reported, while 3 is a sulfated diglycoside. All the glycosides showed significant in vitro cytotoxicities against six tumor cell lines (P-388, A-549, MCF-7, MKN-28, HCT-116,
and U87MG) with IC50 in the range of 0.60–3.95 µM.
Key words
sea cucumber - Cucumariidae -
Pentacta quadrangularis
- triterpene glycosides - cytotoxicity
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1 First co-author.
Prof. Hai-Feng Tang
Department of Pharmacy
Xijing Hospital, Fourth Military Medical University
15 Changle West Rd.
Xi'an 710032
P. R. China
Telefon: + 86 29 84 77 54 71
Fax: + 86 29 84 77 54 71
eMail: tanghaifeng71@163.com