Planta Med 2010; 76(16): 1900-1904
DOI: 10.1055/s-0030-1249854
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Holostane-Type Triterpene Glycosides from the Sea Cucumber Pentacta quadrangularis

Hua Han1 , Qiang-Zhi Xu2 [*] , Hai-Feng Tang3 , Yang-Hua Yi4 , Wei Gong4
  • 1College of Animal Sciences, Zhejiang University, Hangzhou, P. R. China
  • 2Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, P. R. China
  • 3Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, P. R. China
  • 4Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China
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Publikationsverlauf

received December 25, 2009 revised –

accepted April 1, 2010

Publikationsdatum:
27. April 2010 (online)

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Abstract

Two new holostane-type triterpene glycosides, named pentactasides I (1) and II (2), and a new natural product, pentactaside III (3), together with two known glycosides, philinopsides A (4) and B (5), were isolated from the sea cucumber Pentacta quadrangularis. Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. Compounds 1 and 2 possess the same trisaccharide moiety which is a rare structural feature among naturally occurring sea cucumber glycosides and has been infrequently reported, while 3 is a sulfated diglycoside. All the glycosides showed significant in vitro cytotoxicities against six tumor cell lines (P-388, A-549, MCF-7, MKN-28, HCT-116, and U87MG) with IC50 in the range of 0.60–3.95 µM.