Abstract
Zwiebelane A (cis-2,3-dimethyl-5,6-dithiabicyclo[2.1.1]hexane 5-oxide), a natural product of onion bulbs (Allium cepa L.), is found to enhance the potential fungicidal activity of polymyxin B (PMB). As is the case with allicin, an allyl sulfur compound from garlic, zwiebelane A amplifies the disruptive effect of PMB on the vacuole of Saccharomyces cerevisiae, which has been found to represent a target for antifungal agents.
Key words
Allium cepa
- Alliaceae - zwiebelane A - polymyxin B -
Saccharomyces cerevisiae
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Univ.-Prof. Dr. Toshio Tanaka
Department of Bio- and Geosciences
Graduate School of Science
Osaka City University
3–3–138 Sugimoto
Sumiyoshi-ku, Osaka 558–8585
Japan
Telefon: + 81 6 66 05 31 63
Fax: + 81 6 66 05 31 64
eMail: tanakato@sci.osaka-cu.ac.jp
