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Thorac Cardiovasc Surg 2011; 59(3): 184-185
DOI: 10.1055/s-0030-1250341
DOI: 10.1055/s-0030-1250341
Case Reports/Thoracic
© Georg Thieme Verlag KG Stuttgart · New York
Acromegaly Caused by Ectopic Growth Hormone-Releasing Hormone Production from a Bronchial Carcinoid Tumor
Further Information
Publication History
received June 10, 2010
Publication Date:
08 April 2011 (online)

Abstract
Acromegaly is usually caused by a growth hormone (GH)-secreting pituitary adenoma. In rare cases, however, it is caused by the ectopic production of growth hormone-releasing hormone (GHRH). We report a case of acromegaly due to ectopic production of GHRH from a bronchial carcinoid in a 42-year-old female. The carcinoid tumor was successfully treated with bilobectomy.
Key words
Thoracic surgery - acromegaly - bronchial carcinoid
References
- 1 Melmed S. Medical progress: acromegaly. N Engl J Med. 2006; 355 2558-2573
- 2 Biswal S, Srinivasan B, Dutta P et al. Acromegaly caused by ectopic growth hormone: a rare manifestation of a bronchial carcinoid. Ann Thorac Surgery. 2008; 85 330-332
- 3 Losa M, von Werder K. Pathophysiology and clinical aspects of the ectopic GH-releasing hormone syndrome. Clin Endocrinol. 1997; 47 123-135
- 4 Van den Bruel A, Fevery J, van Dorpe J, Hofland L, Bouillon R. Hormonal and volumetric long term control of a growth hormone-releasing hormone producing carcinoid tumor. J Clin Endocrinol Metab. 1999; 84 3162-3169
- 5 De Jager C M, de Heide L J M, van den Berg G, Wolthuis A, van Schelven W D. Acromegaly caused by a growth hormone-releasing hormone secreting carcinoid tumour of the lung: the effect of octreotide treatment. Neth J Med. 2007; 65 263-266
- 6 Osella G, Orlandi F, Caraci P et al. Acromegaly due to ectopic secretion of GHRH by bronchial carcinoid in a patient with empty sella. J Endocrinol Invest. 2003; 26 (2) 163-169
- 7 Scheithauer B W, Carpenter P C, Bloch B, Brazeau P. Ectopic secretion of a growth hormone-releasing factor. Report of a case of acromegaly with bronchial carcinoid tumor. Am J Med. 1984; 76 (4) 605-616
- 8 Athanassiadi K, Exarchos D, Tsagarakis S, Bellenis I. Acromegaly caused by ectopic growth hormone-releasing hormone secretion by a carcinoid bronchial tumor: a rare entity. J Thorac Cardiovasc Surg. 2004; 128 (4) 631-632
- 9 Huber R M, Schopol J, Losa M et al. Growth-hormone releasing hormone in a bronchial carcinoid. Cancer. 1991; 67 2538-2542
- 10 Drange M R, Melmed S. Long-acting lanreotide induces clinical and biochemical remission of acromegaly caused by disseminated growth hormone-releasing hormone-secreting carcinoid. J Clin Endocrinol Metab. 1988; 83 (9) 3104-3109
Prof. Tomas Gudbjartsson, MD, PhD
Department of Cardiothoracic Surgery
Landspitali University Hospital
13 C Hringbraut
101 Reykjavik
Iceland
Phone: +354 5 43 77 55
Fax: +354 5 43 60 76
Email: tomasgud@landspitali.is