New Chalcone and Dimeric Chalcones with 1,4-p-Benzoquinone Residue from Combretum yunnanense

Abstract

New chalcone and dimeric chalcones with 1,4-p-benzoquinone residue, combrequinone A (1), combrequinone B (2), and combrequinone C (3), along with three known compounds (4–6), were isolated from the ethanolic extract of the stems and leaves of Combretum yunnanense, and their structures were determined by spectroscopic analysis. Compounds 1–3 were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, and SW480. Compounds 1, 2, and 3 were found to be most potent against HL-60 acute leukemia cells, with IC₅₀ values of 4.63, 4.07, and 1.26 µM, respectively.

Key words

Combretum yunnanense - Combretaceae - combrequinone A - combrequinone B - combrequinone C - cytotoxicity

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