Labdane Diterpenoids and Shikimic Acid Derivatives from Araucaria cunninghamii

Abstract

Four new (1–4) and two known compounds (5, 6) were isolated from the aerial parts of Araucaria cunninghamii. By analysis of UV, IR, MS, and NMR, the new compounds were identified as ent-19-(Z)-coumaroyloxylabda-8(17),13(16),14-triene (1), ent-19-(E)-coumaroyloxylabda-8(17),13(16),14-triene (2), shikimic acid n-butyl ester (3), and 5-(Z)-coumaroyloxyquinic acid n-butyl ester (4). Compounds 1 and 6 exhibited inhibitory activity against Escherichia coli, and compound 1 also exhibited moderate activity against human leukemia cells (HL-60) and human hepatoma cells (SMMC-7721) with IC₅₀ values of 8.90 and 11.53 µM, respectively.

Key words

Araucaria cunninghamii - Araucariaceae - labdane derivatives - shikimic acid derivatives

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