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Planta Med 2011; 77(8): 841-845
DOI: 10.1055/s-0030-1250609
Biological and Pharmacological Activity
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Neuroprotective Diarylheptanoids from the Leaves and Twigs of Juglans sinensis against Glutamate-Induced Toxicity in HT22 Cells

Heejung Yang1 , Sang Hyun Sung1 , Jinwoong Kim1 , Young Choong Kim1
  • 1College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea
Further Information

Publication History

received October 6, 2010 revised November 16, 2010

accepted November 18, 2010

Publication Date:
14 December 2010 (online)

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Abstract

A new diarylheptanoid, juglanin C (1), was isolated from the 80 % methanolic extract of the leaves and twigs of Juglans sinensis with three known diarylheptanoids, juglanin A (2), juglanin B (3), and (5R)-5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1(4-hydroxyphenyl)-3-heptanone (4), using bioactivity-guided fractionation and chromatographic techniques. Among the isolated diarylheptanoids, compounds 1 and 2 significantly showed neuroprotective activities against glutamate-induced toxicity in HT22 cells. These two diarylheptanoids significantly reduced the overproduction of cellular peroxide in glutamate-injured HT22 cells. Moreover, these two diarylheptanoids significantly maintained antioxidative defense systems, including glutathione, glutathione reductase, and glutathione peroxidase, under glutamate-induced oxidative stress in HT22 cells.

Key words

Juglans sinensis - Juglandaceae - diarylheptanoid - HT22 hippocampal cells - antioxidant activity - neuroprotective

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Prof. PhD Young Choong Kim

College of Pharmacy and Research Institute of Pharmaceutical Sciences
Seoul National University

San 56-1, Sillim-Dong, Gwanak-Gu

Seoul 151-742

Republic of Korea

Phone: + 82 28 80 78 42

Fax: + 82 28 88 29 33

Email: youngkim@snu.ac.kr

    www.thieme-connect.de/ejournals/toc/plantamedica