Small for Gestational Age and Higher Birth Weight Predict Childhood Obesity in Preterm Infants

Ronnesia B Gaskins; Linda L LaGasse; Jing Liu; Seetha Shankaran; Barry M Lester; Henrietta S Bada; Charles R Bauer; Abhik Das; Rosemary D Higgins; Mary Roberts

doi:10.1055/s-0030-1253555

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2010; 27(9): 721-730
DOI: 10.1055/s-0030-1253555

Small for Gestational Age and Higher Birth Weight Predict Childhood Obesity in Preterm Infants

Ronnesia B. Gaskins¹ , Linda L. LaGasse¹ , Jing Liu¹ , Seetha Shankaran² , Barry M. Lester¹ , Henrietta S. Bada³ , Charles R. Bauer⁴ , Abhik Das⁵ , Rosemary D. Higgins⁶ , Mary Roberts¹

¹Center for the Study of Children at Risk, Brown-Alpert Medical School, Women & Infants Hospital of Rhode Island, Providence, Rhode Island
²Department of Pediatrics, Wayne State University, Detroit, Michigan
³University of Kentucky, Lexington, Kentucky
⁴University of Miami Leonard M. Miller School of Medicine, Miami, Florida
⁵RTI International, Rockville, Maryland
⁶Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland

Abstract

ABSTRACT

We sought to determine the association between small for gestational age (SGA), birth weight, and childhood obesity within preterm polysubstance exposed children. We sampled 312 preterm children with 11-year body mass index (BMI; age- and sex-specific) data from the Maternal Lifestyle Study (51% girls, 21.5% SGA, 46% prenatal cocaine, and 55% tobacco exposed). Multinomial regression analyzed the association between 11-year obesity (OBE) and overweight (OW) and SGA, birth weight, first-year growth velocity, diet, and physical activity variables. Overall, 24% were OBE (BMI for age ≥95th percentile) and 16.7% were OW (BMI ≥85th and <95th percentiles). In adjusted analyses, SGA was associated with OW (odds ratio [OR] = 3.4, confidence interval [CI] 1.5 to 7.5). Higher birth weight was associated with OBE (OR = 1.8, CI 1.3 to 2.4) and OW (OR = 1.4, CI 1.1 to 2.0). Growth velocity was associated with OBE (OR = 2.7, CI 1.8 to 4.0) and OW (OR = 1.6, CI 1.1 to 2.4). Low exercise was associated with OBE (OR = 2.1, CI 1.0 to 4.4) and OW (OR = 2.1, CI 1.0 to 4.5). There was no effect of substance exposure on obesity outcomes. Many (41%) of these high-risk preterm 11-year-olds were obese/overweight. Multiple growth-related processes may be involved in obesity risk for preterm children, including fetal programming as indicated by the SGA effect.

KEYWORDS

Childhood obesity - premature birth - infant SGA - birth weight - exercise - prenatal drug exposure

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Referenzen

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Ronnesia B GaskinsPh.D. M.S.P.H.

Brown Center for the Study of Children at Risk, Brown-Alpert Medical School

Women & Infants Hospital of RI, 101 Dudley St., Providence, RI 02905

eMail: Ronnesia_Gaskins@brown.edu